Cryo-EM Structure of the Open Human Ether-à-go-go -Related K + Channel hERG

2017-herg-structure

Weiwei Wang; Roderick MacKinnon

2017-04-01 (print)

Cell (Cell). 169, 3, 422-430.e10. doi:10.1016/j.cell.2017.03.048

PDB codes

5va1, 5va2, 5va3

kv

Structures of closed and open states of a voltage-gated sodium channel

2017-navab

Michael J. Lenaeus; Tamer M. Gamal El-Din; Christopher Ing; Karthik Ramanadane; Régis Pomès; Ning Zheng; William A. Catterall

2017-03-27 (online) – 2017-04-11 (print)

Proceedings of the National Academy of Sciences (Proc. Natl. Acad. Sci. U.S.A.). 114, 15, E3051-E3060. doi:10.1073/pnas.1700761114

Description

Open PD/VSD (5vb8) and closed PD/VSD/CTD (5vb2)

PDB codes

5vb8, 5vb2

nav structure

The complete structure of an activated open sodium channel

2017-open-full-navms

Altin Sula; Jennifer Booker; Leo C. T. Ng; Claire E. Naylor; Paul G. DeCaen; B. A. Wallace

2017-02-16 (online)

Nature Communications (Nat. Commun.). 8, 14205. doi:10.1038/ncomms14205

Description

First full-length, open conformation. 2017-navab has a full-length closed. This is NavMs and that is NavAb.

PDB codes

5hvx, 5hvd

nav structure

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

2017-euk-navpas

Huaizong Shen; Qiang Zhou; Xiaojing Pan; Zhangqiang Li; Jianping Wu; Nieng Yan

2017-02-09 (online) – 2017-03-03 (print)

Science (Science). 355, 6328, eaal4326. doi:10.1126/science.aal4326

Description

First eukaryotic structure. CryoEM of cockroach NaV. Might not be a NaV. No elecrophysiology can be performed. Was originally called PaFPC1, they renamed it NaVPaS

PDB codes

5x0m

nav structure

Simulating the Activation of Voltage Sensing Domain for a Voltage-Gated Sodium Channel Using Polarizable Force Field

2017-vsd-only-pmf

Rui-Ning Sun; Haipeng Gong

2017-02-09 (online) – 2017-03-02 (print)

The Journal of Physical Chemistry Letters (J. Phys. Chem. Lett.). 8, 5, 901-908. doi:10.1021/acs.jpclett.7b00023

Description

They simulated only one domain. They took the NavAb vsd and connected it via molecular dynamics to a homology model to a sea squirt vsd. They used a polarizable force-field, which is more expensive than normal (fixed charge) forcefields but that might be important for something so intertwined with moving electrical charges!

nav

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

2016-cav-structure

Jianping Wu; Zhen Yan; Zhangqiang Li; Xingyang Qian; Shan Lu; Mengqiu Dong; Qiang Zhou; Nieng Yan

2016-08-31 (online)

Nature (Nature). 537, 7619, 191-196. doi:10.1038/nature19321

Description

Cav structure. What's the diference between 2015-cav-structure

PDB codes

5gjv, 5gjw

cav

The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides

2016-btx-insect

Yongqiang Zhang; Yuzhe Du; Dingxin Jiang; Caitlyn Behnke; Yoshiko Nomura; Boris S. Zhorov; Ke Dong

2016-08-03 (online) – 2016-09-16 (print)

Journal of Biological Chemistry (J. Biol. Chem.). 291, 38, 20113-20124. doi:10.1074/jbc.M116.742056

Description

Homology model to open cockroach channel and docking study

nav

Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs

2016-btx-frogs

Rebecca D. Tarvin; Juan C. Santos; Lauren A. O'Connell; Harold H. Zakon; David C. Cannatella

2016-01-18 (online) – 2016-04-01 (print)

Molecular Biology and Evolution (Mol. Biol. Evol.). 33, 4, 1068-1081. doi:10.1093/molbev/msv350

Description

Evolutionary analysis and docking study on NaV 1.4 in frogs immune to toxins

nav

Structure of the voltage-gated calcium channel Cav1.1 complex

2015-cav-structure

J. Wu; Z. Yan; Z. Li; C. Yan; S. Lu; M. Dong; N. Yan

2015-12-17 (online) – 2015-12-18 (print)

Science (Science). 350, 6267, aad2395-aad2395. doi:10.1126/science.aad2395

Description

also a cav structure.

PDB codes

3jbr

cav

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

2014-closed-navae1p

David Shaya; Felix Findeisen; Fayal Abderemane-Ali; Cristina Arrigoni; Stephanie Wong; Shailika Reddy Nurva; Gildas Loussouarn; Daniel L. Minor

2014-01-01 (print)

Journal of Molecular Biology (J. Mol. Biol.). 426, 2, 467-483. doi:10.1016/j.jmb.2013.10.010

Description

Closed Pore and CTD in pore-only NavAe. Correlates CTD neck unfolding with activation.

PDB codes

4lto, 4ltp, 4ltq, 4ltr

nav structure

Role of the C-terminal domain in the structure and function of tetrameric sodium channels

2013-open-pore-navms

Claire Bagnéris; Paul G. DeCaen; Benjamin A. Hall; Claire E. Naylor; David E. Clapham; Christopher W. M. Kay; B. A. Wallace

2013-09-19 (online)

Nature Communications (Nat. Commun.). 4, doi:10.1038/ncomms3465

Description

Pore only open conformation. Supposed to have the CTD but rcsb pdb doesn't show it. Proposes CTD role in gating.

PDB codes

3zjz

nav structure

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

2012-partially-open-pore-navms

Emily C. McCusker; Claire Bagnéris; Claire E. Naylor; Ambrose R. Cole; Nazzareno D'Avanzo; Colin G. Nichols; B.A. Wallace

2012-10-02 (online)

Nature Communications (Nat. Commun.). 3, 1102. doi:10.1038/ncomms2077

Description

Pore only partially open state. This may or may not collapse to the closed state in molecular dynamics.

PDB codes

4f4l

nav structure

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

2012-closed-navrh

Xu Zhang; Wenlin Ren; Paul DeCaen; Chuangye Yan; Xiao Tao; Lin Tang; Jingjing Wang; Kazuya Hasegawa; Takashi Kumasaka; Jianhua He; Jiawei Wang; David E. Clapham; Nieng Yan

2012-05-20 (online)

Nature (Nature). doi:10.1038/nature11054

Description

Pore and Voltage Sensing domains in a closed state.

PDB codes

4dxw

nav structure

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

2012-closed-asym-navab

Jian Payandeh; Tamer M. Gamal El-Din; Todd Scheuer; Ning Zheng; William A. Catterall

2012-05-20 (online)

Nature (Nature). doi:10.1038/nature11077

Description

Pore and Voltage Sensing domains in an asymmetric closed state. NavAb.

PDB codes

4ekw

nav structure

Structural basis for gating charge movement in the voltage sensor of a sodium channel

2012-vsd-mechanism

V. Yarov-Yarovoy; P. G. DeCaen; R. E. Westenbroek; C.-Y. Pan; T. Scheuer; D. Baker; W. A. Catterall

2011-12-12 (online) – 2012-01-10 (print)

Proceedings of the National Academy of Sciences (Proc. Natl. Acad. Sci. U.S.A.). 109, 2, E93-E102. doi:10.1073/pnas.1118434109

Description

Homology modelling to resting, intermediate and activated states of voltage sensing domains. Disulfide locking experiments. Cites [doi:10.1073/pnas.0806486105] and [doi:10.1073/pnas.0912307106] and [doi:10.1073/pnas.1116449108]

nav

The crystal structure of a voltage-gated sodium channel

2011-closed-navab

Jian Payandeh; Todd Scheuer; Ning Zheng; William A. Catterall

2011-07-10 (online)

Nature (Nature). 475, 7356, 353-358. doi:10.1038/nature10238

Description

Pore and Voltage Sensing domains in a closed state. First NaV Structure. Prokaryote NavAb

PDB codes

3rvy, 3rvz, 3rw0

nav structure